Development of MIP-based QCM Sensors for Determination of Hyaluronic Acid (HA)

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Sibel Emir Diltemiz

Abstract

In this study, quartz crystal microbalance (QCM) based recognition systems have been developed for the determination of hyaluronic acid (HA). For this purpose, firstly; N-methacryloyl-l-tyrosine (MAT), MAT-D-Glucuronic acid (MAT-D-GA) and MAT-Cu(II)-D-Glucuronic acid (MAT-Cu(II)-D-GA) pre-organized monomers have been synthesized, and characterized. Then, D-glucuronic acid active sites of HA biomacromolecule have recognized and synthesized onto sensors using selective imprinting strategies to HA molecule. In the last step, the binding interactions, usabilities in recognition and determination of prepared sensors have been investigated.

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How to Cite
DILTEMIZ, Sibel Emir. Development of MIP-based QCM Sensors for Determination of Hyaluronic Acid (HA). Hacettepe Journal of Biology and Chemistry, [S.l.], v. 46, n. 2, p. 273-283, may 2018. ISSN 1303-5002. Available at: <http://hjbc.hacettepe.edu.tr/index.php/hjbc/article/view/97>. Date accessed: 22 sep. 2018.
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