CYTOTOXIC EFFECTS OF NOVEL THIAZOLO[3,2-C]PYRIMIDINES AGAINST MCF-7 AND HEPG2/C3A CARCINOMA CELL LINES

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Arzu BİRİNCİ YILDIRIM Esra MUTLU Muhammet Yıldırım

Abstract

In the present study, a series of novel thiazolo[3,2-c]pyrimidines (4,5) have been produced via simple and efficient synthetic method and their in vitro cytotoxicities have been performed on human breast (MCF-7) and hepatocellular (HEPG2/C3A) adenocarcinoma cell lines. The results of these in vitro tests revealed that at least five of thiazolo[3,2-c]pyrimidines exhibited very strong cytotoxic effects at very low doses, which were very similar or lower than that of reference anticancer agent, 5-FU, against human breast (MCF-7) and HEPG2/C3A cancer cell lines.

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How to Cite
YILDIRIM, Arzu BİRİNCİ; MUTLU, Esra; YILDIRIM, Muhammet. CYTOTOXIC EFFECTS OF NOVEL THIAZOLO[3,2-C]PYRIMIDINES AGAINST MCF-7 AND HEPG2/C3A CARCINOMA CELL LINES. Hacettepe Journal of Biology and Chemistry, [S.l.], v. 46, n. 2, p. 237-246, may 2018. ISSN 1303-5002. Available at: <http://hjbc.hacettepe.edu.tr/index.php/hjbc/article/view/96>. Date accessed: 17 july 2018.
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