ELECTROANALYTICAL STUDIES AND SIMULTANEOUS VALIDATED ASSAY OF ANTIHYPERTENSIVE COMPOUNDS IN THEIR BINARY MIXTURES USING FAST ELECTROCHEMICAL TECHNIQUE

Abstract

The electrochemical behavior of amlodipine (AML) and telmisartan (TLM) on a glassy carbon electrode were investigated in different aqueous solutions by using cyclic, differential pulse, and square wave voltammetric techniques. AML and TLM exhibited one peak (both of them) to the anodic direction. The oxidation process was found to be irreversible and adsorption controlled. To obtain good sensitivity, the instrumental and accumulation variables were studied using square wave voltammetry (SWV) techniques in 0.5 M H₂SO₄ solution, which was obtained as the most repeatabile and sensitive media. In this study; sensitive, fast and reliable method development was aimed for simultaneous detection of AML and TLM. This voltammetric method exhibited linear dynamic responses in the concentration range between 1.0×10^-7 M and 1.0×10^-4 M for AML and 1.0×10^-7 M and 1.0×10^-5 M for TLM, with detection limits of 0.654 nM and 22.6 nM, respectively. The proposed method is validated and successfully applied for the analysis of AML and TLM tablets.